Evaluation of Effectiveness of Combined Intra-articular and Intra-osseus Injection VS a Single Intra-articular Injection of Bone Marrow Concentrate

Summary

Osteoarthritis (OA) is one of the most common diseases resulting in large burdens on society. Among the emerging treatments, Bone Marrow Concentrate (BMC) intra-articular injections are a promising regenerative approach. However, they offer only a temporary benefit since they target synovial and chondral tissues but fail to address the osteochondral interface, which plays a key role in the onset and progression of joint degeneration. This project will investigate the efficacy of combined BMC injections, targeting both intra-articular tissues and subchondral bone, to treat OA in a Randomized Controlled Trial (RCT).

Timeline

Start

2019-11-08

Primary completion

2023-03-01

Completion

2023-03-01

Publications

• Silva S, Andriolo L, Boffa A, Di Martino A, Reale D, Vara G, Miceli M, Cavallo C, Grigolo B, Zaffagnini S, Filardo G. Prospective double-blind randomised controlled trial protocol comparing bone marrow aspirate concentrate intra-articular injection combined with subchondral injection versus intra-articular injection alone for the treatment of symptomatic knee osteoarthritis. BMJ Open. 2022 Sep 8;12(9):e062632. doi: 10.1136/bmjopen-2022-062632.

Drugs

Indications