drugset / Trial / NCT03878082
Propacetamol to Reduce Post Cesarean Section Uterine Contraction Pain
RandomizedParallel-groupDouble-blindTreatment
Summary
To evaluate that perioperative regular usage of propacetamol to reduce post cesarean section uterine contraction pain and opioid consumption
Timeline
- Start
- 2019-08-12
- Primary completion
- 2022-12-30
- Completion
- 2022-12-31
Publications
- Background Valentine AR, Carvalho B, Lazo TA, Riley ET. Scheduled acetaminophen with as-needed opioids compared to as-needed acetaminophen plus opioids for post-cesarean pain management. Int J Obstet Anesth. 2015 Aug;24(3):210-6. doi: 10.1016/j.ijoa.2015.03.006. Epub 2015 Mar 23.
- Background Ortiz MI, Ponce-Monter HA, Mora-Rodriguez JA, Barragan-Ramirez G, Barron-Guerrero BS. Synergistic relaxing effect of the paracetamol and pyrilamine combination in isolated human myometrium. Eur J Obstet Gynecol Reprod Biol. 2011 Jul;157(1):22-6. doi: 10.1016/j.ejogrb.2011.02.011. Epub 2011 Mar 24.
- Background Gadsden J, Hart S, Santos AC. Post-cesarean delivery analgesia. Anesth Analg. 2005 Nov;101(5 Suppl):S62-S69. doi: 10.1213/01.ANE.0000177100.08599.C8.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Propacetamol | Small molecule | 1 g | Intravenous |
| Comparator | Propacetamol | Small molecule | 2 g | Intravenous |