Understanding Cognition, Oxytocin & Pain in Elders

Summary

Osteoarthritis (OA) represents a significant cause of disability worldwide and the knee is the most commonly affected joint. Oxytocin (OT) is a mediator of endogenous analgesia in animal and human studies. This proposal will test the efficacy and safety of self-administered intranasal OT over 4-weeks in older individuals relative to placebo (P) evaluating its effects on pain and function in aging and testing potential underlying neurobiological mechanisms.

Timeline

Start

2019-08-06

Primary completion

2024-12-19

Completion

2024-12-19

Publications

• Cruz-Almeida Y, Montesino-Goicolea S, Valdes-Hernandez P, Huo Z, Staud R, Ebner NC. Understanding Cognition, Oxytocin, and Pain in Elders (UCOPE): protocol for a double-blinded cross-over trial in chronic knee osteoarthritis pain. Trials. 2025 Feb 7;26(1):44. doi: 10.1186/s13063-024-08715-4.

Drugs

Indications