Physiologic Approach to Sodium Supplementation in Premature Infants

Phase 4 Completed 90 enrolled Indiana University Thrasher Research Fund · collab

RandomizedParallel-groupSingle-blindPrevention

Summary

Postnatal growth failure occurs in up to 50% of very low birth weight (VLBW, \<1500 grams at birth) infants as assessed by discharge weight. This study will evaluate if a sodium supplementation algorithm guided by spot urine sodium measurements can improve postnatal growth.

Timeline

Start: 2019-07-01
Primary completion: 2023-07-22
Completion: 2023-08-15

Publications

Background Segar DE, Segar EK, Harshman LA, Dagle JM, Carlson SJ, Segar JL. Physiological Approach to Sodium Supplementation in Preterm Infants. Am J Perinatol. 2018 Aug;35(10):994-1000. doi: 10.1055/s-0038-1632366. Epub 2018 Feb 27.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Sodium supplementation	Unknown	2 meq	—
Comparator	Sodium supplementation	Unknown	4 meq	—

Indications

No indication recorded.