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drugset / Trial / NCT03892499

A Trial to Evaluate the Effect of Itraconazole (ITZ), a CYP3A4 Inhibitor, on the Pharmacokinetics of the Soluble Guanylate Cyclase Stimulator, Olinciguat (IW-1701), in Healthy Volunteers

NCT03892499 ↗

Phase 1 Completed 24 enrolled Cyclerion Therapeutics
NaSingle-groupOpen-labelOther

Summary

To evaluate the effect of itraconazole (a potent cytochrome P450 isoenzyme \[CYP\]3A inhibitor) on the pharmacokinetics (PK) of olinciguat

Timeline

Start
2019-05-03
Primary completion
2019-06-23
Completion
2019-07-03

Drugs

EvaluationDrugModalityDoseRoute
Subject Itraconazole Small molecule — Oral
Subject Olinciguat Small molecule — Oral

Indications

No indication recorded.