drugset / Trial / NCT03893617

Brief Stresses Experimental Study

NCT03893617

RandomizedParallel-groupTriple-blindBasic science

Summary

The goal of this study is to examine the impact of psychological stress on DNA integrity by conducting an experiment under controlled conditions with healthy volunteers to directly test the extent to which acute stress increases DNA damage, while simultaneously testing the blocking effects of pre-treatment with propranolol, and exploring key hypothesized mediators and moderators of the severity of the DNA damage.

Timeline

Start
2017-10-05
Primary completion
2022-01-27
Completion
2022-01-27

Drugs

EvaluationDrugModalityDoseRoute
Comparator Propranolol Small molecule 80 mg Oral

Indications