drugset / Trial / NCT03894189
The Effect of Doxapram Versus Theophylline on Diaphragmatic Function
RandomizedParallel-groupOpen-labelSupportive care
Summary
Doxapram is licensed for drug-induced post-anesthesia respiratory depression , arousal effect and return airway protective reflexes caused by barbiturates, volatile anesthetics, nitrous oxide or benzodiazepines over dosage. Value of theophylline to stimulate the respiratory neuronal network has been examined by previous studies and increases the activity of respiratory muscles, including the intercostal , transversus abdominis muscles and the diaphragm, it also has bronchodilator and anti-inflammatory effects.
Timeline
- Start
- 2019-05
- Primary completion
- 2019-12
- Completion
- 2019-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Doxapram | Small molecule | 1 mg/kg | — |
| Comparator | Theophylline | Small molecule | 0.5 mg/kg | — |
Indications
No indication recorded.