New Ovarian Stimulation With Random Start, Use of Progestin Protocol for Oocyte Donors

Summary

Oocyte donation is a cumbersome and demanding procedure, involving an injectable hormonal treatment for an average duration of 12 days, according to the protocols, 1 to several daily injections. The objective of this study is to show that treatments can be simplified without reducing the number of oocytes that have been punctured, by blocking the luteinizing hormone (LH) surge by using oral progesterone and by limiting the number of injections of gonadotropins using corifollitropin alpha, regardless of the start date of the pacing protocol during a natural cycle.

Timeline

Start

2020-09-04

Primary completion

2023-10-30

Completion

2023-10-30

Publications

• Mathieu d'Argent E, Guivarc'h-Leveque A, Catteau-Jonard S, Cedrin-Durnerin I, Peigne M, Jung C, Goro S, Wang XX, Massin N. Feasibility and efficacy of random-start progestin-primed ovarian stimulation: a multicenter pilot randomized controlled trial in oocyte donation. Reprod Biol Endocrinol. 2025 Dec 10;24(1):7. doi: 10.1186/s12958-025-01509-6.

Drugs

Indications