Collagenase Clostridium Histolyticum for Refractory Iatrogenic Esophageal Strictures

Summary

In this open-label pilot study we want to investigate whether intralaesional injection with collagenase clostridium histolyticum (XiapexR) into the esophageal stricture followed by dilation 24 hours later improves the outcome of patients with refractory esophageal anastomotic strictures as compared to dilation alone (standard of care).

Timeline

Start

2019-03-29

Primary completion

2020-06-30

Completion

2021-01-01

Outcome

Outcome not reported

Stopped: “unexpected serious adverse event”

Drugs

Indications