drugset / Trial / NCT03905486

Efficacy of Pregabalin Versus Combined Pregabalin and Milnacipran in Fibromyalgia.

NCT03905486

Completed 58 enrolled Yousra Hisham Abdel Fattah
RandomizedParallel-groupOpen-labelTreatment

Summary

Diagnosis of fibromyalgia is complex and treatment options are limited. Pharmacological management of fibromyalgia is mainly centered on the central nervous system. In particular there is robust evidence for the use of tricyclic antidepressants (e.g., amitriptyline), anti-convulsants such as gabapentin or pregabalin and agents from the serotonin norepinephrine reuptake inhibitor (SNRI) family such as milnacipran. Aim of the work: To compare the efficacy of pregabalin agent (averopreg) alone versus combined pregabalin and serotonin norepinephrine reuptake inhibitor (milnacipran) in the management of fibromyalgia.

Timeline

Start
2019-04-01
Primary completion
2019-11-30
Completion
2019-12-31

Drugs

EvaluationDrugModalityDoseRoute
Comparator Milnacipran Other / unclassified 100 mg
Comparator Pregabalin Small molecule 300 mg

Indications