drugset / Trial / NCT03905603

Relative Contributions of Predictors of Hyperandrogenism in Older vs. Young Women With PCOS

NCT03905603 ↗

Phase 0 Unknown 144 enrolled University of Virginia
NaSingle-groupOpen-labelBasic science

Summary

The objective of the study is to determine the relative contributions of four established predictors of hyperandrogenism (luteinizing hormone \[LH\] secretion, ovarian response to recombinant human chorionic gonadotropin \[r-hCG\] administration, adrenal response to adrenocorticotropic hormone \[ACTH\] administration, and hyperinsulinemia) in older vs. young women with Polycystic Ovary Syndrome (PCOS) in a cross-sectional, physiological study. The investigators hypothesize that hyperinsulinemia is a stronger independent predictor of free testosterone (T) in older reproductive aged (vs. young) women with PCOS.

Timeline

Start
2019-10-08
Primary completion
2026-04-01
Completion
2026-05-01

Drugs

EvaluationDrugModalityDoseRoute
Subject ACTH Unknown 250 ug Intravenous
Subject rhCG Unknown 250 ug Intravenous