drugset / Trial / NCT03905603
Relative Contributions of Predictors of Hyperandrogenism in Older vs. Young Women With PCOS
NaSingle-groupOpen-labelBasic science
Summary
The objective of the study is to determine the relative contributions of four established predictors of hyperandrogenism (luteinizing hormone \[LH\] secretion, ovarian response to recombinant human chorionic gonadotropin \[r-hCG\] administration, adrenal response to adrenocorticotropic hormone \[ACTH\] administration, and hyperinsulinemia) in older vs. young women with Polycystic Ovary Syndrome (PCOS) in a cross-sectional, physiological study. The investigators hypothesize that hyperinsulinemia is a stronger independent predictor of free testosterone (T) in older reproductive aged (vs. young) women with PCOS.
Timeline
- Start
- 2019-10-08
- Primary completion
- 2026-04-01
- Completion
- 2026-05-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | ACTH | Unknown | 250 ug | Intravenous |
| Subject | rhCG | Unknown | 250 ug | Intravenous |