Evaluation of Nicotinamide Riboside in Prevention of Small Fiber Axon Degeneration and Promotion of Nerve Regeneration

Summary

This study will evaluate the effects of a nutritional supplement called nicotinamide riboside in preventing small fiber nerve degeneration that is experimentally induced by applying capsaicin to skin in otherwise healthy study participants. Furthermore, the effects on nerve regeneration will also be evaluated. The results will be compared to a placebo control drug.

Timeline

Start

2020-09-01

Primary completion

2023-05-01

Completion

2023-05-30

Outcome

Missed primary endpoint

registry analysis (superiority test); Nicotinamide Riboside vs Placebo; p = 0.33; Wilcoxon (Mann-Whitney) NCT03912220 ↗

registry analysis (superiority test); Nicotinamide Riboside vs Placebo; p = 0.54; Wilcoxon (Mann-Whitney) NCT03912220 ↗

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Nicotinamide riboside	Small molecule	900 mg	Oral

Indications