PHNA, Efficacy of Tretinoin Cream on Post-phototherapy Hyperpigmentation

Completed 25 enrolled The Catholic University of Korea

RandomizedParallel-groupSingle-blindPrevention

Summary

A randomized controlled split-face pilot study was planned to investigate the preventive effect of tretinoin 0.05% cream on hyperpigmentation during phototherapy in patients with vitiligo.

Timeline

Start: 2019-04-29
Primary completion: 2019-11-19
Completion: 2019-11-29

Outcome

Met primary endpoint

paper The delta L* value was significantly different between the two groups: -0.5% in the tretinoin group and -8.7% in the control group at 12 weeks (p = .002). PMID 32869680 ↗

paper CONCLUSIONS: Tretinoin 0.05% cream prevented hyperpigmentation during NBUVB phototherapy in patients with facial vitiligo, and did not compromise the overall treatment response. PMID 32869680 ↗

Publications

Ju HJ, Kim SH, Lee JH, Kim GM, Bae JM. Efficacy and safety of tretinoin 0.05% cream to prevent hyperpigmentation during narrowband UV-B phototherapy in patients with facial vitiligo: a randomized clinical trial. J Dermatolog Treat. 2022 May;33(3):1738-1741. doi: 10.1080/09546634.2020.1817298. Epub 2020 Sep 10.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Tretinoin	Unknown	0.05 %	Topical