Follicular Phase Stimulation vs. Luteal Phase Stimulation in Patients Diagnosed With Suboptimal Response

Summary

This study aims to investigate the difference in the number of oocytes obtained by performing ovarian stimulation in follicular phase vs. luteal phase in a population of patients with previous suboptimal response. This is a controlled randomized clinical study. We aim to include 41 patients diagnosed with suboptimal response who will undergo an ovarian stimulation in order to vitrify and accumulate oocytes. The main variable for evaluating the efficacy in this exploratory study will be the number of oocyte cumulus complexes obtained.

Timeline

Start

2020-01-17

Primary completion

2022-04-02

Completion

2022-04-02

Outcome

Missed primary endpoint

paper The mean number of cumulus-oocyte complexes retrieved was similar between the FPS and LPS groups PMID 38204945 ↗

paper CONCLUSIONS: In this study, the oocyte yield in LPS did not increase in suboptimal responders compared with that in FPS PMID 38204945 ↗

Publications

• Sunol J, Castillo JC, Ortiz JA, Ten J, Fuentes A, Moliner B, Martinez M, Llacer J, Guerrero J, Pitas A, Bernabeu A, Bernabeu R. Conventional follicular-phase ovarian stimulation vs. luteal-phase stimulation in suboptimal responders: a randomized controlled trial. F S Rep. 2023 Jul 27;4(4):344-352. doi: 10.1016/j.xfre.2023.07.003. eCollection 2023 Dec.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Corifollitropin alfa	Protein / enzyme biologic	—	—

Indications

No indication recorded.