Autologous Volar Fibroblast Injection Into the Stump Site of Amputees

Phase 2 Recruiting 50 enrolled Johns Hopkins University Maryland Stem Cell Research Fund · collab National Institutes of Health (NIH) · collab United States Department of Defense · collab

RandomizedCrossoverDouble-blindPrevention

Summary

This study is a clinical trial testing the safety and efficacy of volar fibroblast (skin cells from the palm or sole) injections for thickening the epidermal (skin) layer at the stump site in people with below the knee amputations. The study will enroll adults seen at Johns Hopkins.

Timeline

Start: 2019-09-05
Primary completion: 2028-04-01
Completion: 2028-04-01

Publications

Tsai J, Rostom M, Garza LA. Understanding and Harnessing Epithelial-Mesenchymal Interactions in the Development of Palmoplantar Identity. J Invest Dermatol. 2022 Feb;142(2):282-284. doi: 10.1016/j.jid.2021.06.016. Epub 2021 Aug 6.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Autologous Skin Fibroblasts	Cell therapy	—	Other

Indications

No indication recorded.