Characterization of the Relationship Between the Human Mesolimbic Reward System and Immune Functioning

Summary

The purpose of this study is to characterize the link between neurobehavioral measures of the mesolimbic reward system and immune functioning in healthy individuals, via fMRI neurofeedback modulation of mesolimbic reward system, and the consecutive assesment of immune response to Hepatitis B vaccination.

Timeline

Start

2019-01-20

Primary completion

2022-08-28

Completion

2022-08-28

Publications

• Lubianiker N, Koren T, Djerasi M, Sirotkin M, Singer N, Jalon I, Lerner A, Sar-El R, Sharon H, Shahar M, Azulay-Debby H, Rolls A, Hendler T. Upregulation of reward mesolimbic activity and immune response to vaccination: a randomized controlled trial. Nat Med. 2026 Feb;32(2):572-581. doi: 10.1038/s41591-025-04140-5. Epub 2026 Jan 19.

Drugs

Indications