Anti-oxidant Therapy and Postoperative Cardiac Events (ACE) Trial, Preoperative Intervention in Vascular Surgery

Phase 0 Unknown 341 enrolled Minneapolis Veterans Affairs Medical Center

RandomizedParallel-groupQuadruple-blindTreatment

Summary

N Terminal (NT)-Pro b-type natriuretic peptide (BNP) levels provide incremental value in perioperative risk assessment prior to major non-cardiac surgery. The investigators will test whether pharmacologically lowering this biomarker with daily administration of CoQ10 for 3 days prior to elective vascular surgery will reduce adverse outcomes following the operation.

Timeline

Start: 2013-08-05
Primary completion: 2022-08-04
Completion: 2022-08-04

Publications

Khan A, Johnson DK, Carlson S, Hocum-Stone L, Kelly RF, Gravely AA, Mbai M, Green DL, Santilli S, Garcia S, Adabag S, McFalls EO. NT-Pro BNP Predicts Myocardial Injury Post-vascular Surgery and is Reduced with CoQ10: A Randomized Double-Blind Trial. Ann Vasc Surg. 2020 Apr;64:292-302. doi: 10.1016/j.avsg.2019.09.017. Epub 2019 Oct 17.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Coenzyme Q10	Other / unclassified	400 mg	Oral

Indications

No indication recorded.