Neurobehavioral Mechanisms of Choice in Opioid Use Disorder

Summary

The objective of this protocol is to use probabilistic reinforcement learning choice tasks and magnetic resonance neuroimaging to demonstrate the impact of problematic opioid use and opioid withdrawal on dynamic decision-making and reveal the neurobehavioral and neurobiological processes underlying abnormal task performance. A second objective is to identify an appropriate dose of intravenous remifentanil for subsequent studies in physically dependent individuals with opioid use disorder.

Timeline

Start

2019-08-16

Primary completion

2025-07-10

Completion

2025-07-10

Drugs

Indications