drugset / Trial / NCT03960177
Glucarpidase After High-Dose Methotrexate in Patients With Osteosarcoma
Phase 0
Completed
11 enrolled
OHSU Knight Cancer Institute
BTG International Inc. · collabOregon Health and Science University · collab
NaSingle-groupOpen-labelTreatment
Summary
This early phase I trial studies how well glucarpidase works in reducing toxicity in patients with osteosarcoma receiving high dose methotrexate treatment. Glucarpidase may reduce the levels of methotrexate in patients' blood and lead to shorter hospitalizations and a reduction in toxicities.
Timeline
- Start
- 2019-03-27
- Primary completion
- 2025-12-31
- Completion
- 2025-12-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Glucarpidase | Protein / enzyme biologic | 1000 iu | Intravenous |