drugset

drugset / Trial / NCT03968211

Undetectable IgE as a Sentinel Biomarker for Humoral Immunodeficiency

NCT03968211 ↗

Phase 1 Completed 37 enrolled University of Virginia CSL Behring · collab Jeffrey Modell Foundation · collab

NaSingle-groupOpen-labelDiagnostic

Summary

This study is trying to find out if an undetectable serum immunoglobulin E (IgE) is a biomarker, or early sign of, the development of immune deficiency.

Timeline

Start: 2019-07-01
Primary completion: 2023-12-31
Completion: 2023-12-31

Publications

Background Lawrence MG, Palacios-Kibler TV, Workman LJ, Schuyler AJ, Steinke JW, Payne SC, McGowan EC, Patrie J, Fuleihan RL, Sullivan KE, Lugar PL, Hernandez CL, Beakes DE, Verbsky JW, Platts-Mills TAE, Cunningham-Rundles C, Routes JM, Borish L. Low Serum IgE Is a Sensitive and Specific Marker for Common Variable Immunodeficiency (CVID). J Clin Immunol. 2018 Apr;38(3):225-233. doi: 10.1007/s10875-018-0476-0. Epub 2018 Feb 17.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Typhim Vi	Vaccine	—	Intramuscular

Indications