Serotonin in Impulse Control Disorders in Parkinson's Disease

Summary

Impulse control disorders are frequent and troublesome in patients with Parkinson's disease. However, the cerebral functional alterations related to impulse control disorders in Parkinson's disease are poorly understood and may involve the serotoninergic system besides alterations in the dopaminergic system. The primary objective of this study is to investigate the cerebral functional alterations in the serotoninergic system in patients with Parkinson's disease and impulse control disorders using Positron Emission Tomography with highly specific radiotracers of serotonin transporter (SERT) using \[11 Carbon\]-3-amino-4-(2-dimethylaminomethylphenylsulfanyl)-benzonitrile (\[11C\]-DASB) and of serotonin 5-Hydroxytryptamine 2A (5-HT2A) receptor using \[18 Fluorine\]-altanserin (\[18F\]-altanserin), in comparison to patients with Parkinson's disease without impulse control disorders and healthy volunteers.

Timeline

Start

2019-05-13

Primary completion

2022-02-13

Completion

2022-02-13

Drugs

Indications