drugset / Trial / NCT03970993
VAC 072-An Efficacy Study of R21/MM in Different Dose Schedules
Non-randomizedParallel-groupOpen-labelPrevention
Summary
An open label, partially blinded clinical trial in which healthy volunteers will be administered experimental malaria vaccines. There will be seven experimental groups of volunteers, of which five receive vaccination with the novel malaria vaccine candidate, R21, in combination with the vaccine adjuvant, Matrix M. The study will assess the safety \& immune responses to vaccination, and the efficacy of the vaccine.
Timeline
- Start
- 2019-06-17
- Primary completion
- 2021-08-24
- Completion
- 2021-08-24
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | R21 | Vaccine | 2 ug | Intramuscular |
| Subject | R21 | Vaccine | 10 ug | Intramuscular |
| Subject | R21 | Vaccine | 50 ug | Intramuscular |
| Background | Matrix-M1 Adjuvant | Other / unclassified | 50 ug | Intramuscular |