drugset / Trial / NCT03975270

Sintilimab in Combination With Nab-paclitaxel in Patients With HNSCC (Head and Neck Squamous Cell Carcinoma )

NCT03975270 ↗

Phase 2 Unknown 41 enrolled Shengyu Zhou
NaSingle-groupOpen-labelTreatment

Summary

Clinical studies related to immunotherapy of HNSCC have shown that PD1 monoclonal antibody has better clinical benefits than conventional chemotherapy. This phase II clinical study is a single arm, open, single-center study. The aim of this study is to observe and evaluate the efficacy and safety of Sintilimab combined with paclitaxel-albumin-binding for injection in patients with advanced recurrent and metastatic HNSCC who fail to receive first-line or more treatment. Participation in this study for treatment may benefit patients with advanced recurrence or metastasis of HNSCC.

Timeline

Start
2019-07-20
Primary completion
2021-05-31
Completion
2021-05-31

Drugs

EvaluationDrugModalityDoseRoute
Subject Nab-paclitaxel Small molecule 120 mg/m2 Intravenous
Subject Sintilimab Monoclonal antibody 200 mg Intravenous