drugset / Trial / NCT04000919
Effects of 5HTP and LDOPA on CNS Excitability After SCI
RandomizedCrossoverDouble-blindBasic science
Summary
This study will examine whether supplementation with the serotonin and dopamine precursors, 5HTP and L-DOPA can alter central nervous system excitability and improve motor function after incomplete and complete spinal cord injuries.
Timeline
- Start
- 2019-06-19
- Primary completion
- 2023-06-30
- Completion
- 2023-12-30
Outcome
Outcome not reported
Stopped: “PI left UofL and intends to reopen study at University of Alberta”
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | 5HTP | Other / unclassified | 50 mg | — |
| Comparator | 5HTP | Other / unclassified | 200 mg | — |
| Comparator | Carbidopa | Unknown | 50 mg | — |
| Comparator | L-dopa | Peptide | 50 mg | — |
| Comparator | L-dopa | Peptide | 200 mg | — |