drugset / Trial / NCT04002310

A Study to Test How Well Different Doses of BI 754132 Are Tolerated in Patients With an Advanced Form of Age-related Macular Degeneration Called Geographic Atrophy

NCT04002310 ↗

Phase 1 Terminated 18 enrolled Boehringer Ingelheim
Non-randomizedSequentialOpen-labelTreatment

Summary

This is a study in adults with geographic atrophy, an advanced form of age-related macular degeneration. The purpose of this study is to find out how well different doses of BI 754132 are tolerated. The participants are in the study for about 4 months. During this time, they visit the study site about 10 times. Participants receive 1 injection of BI 754132 directly into one of the eyes affected by geographic atrophy. In this study, BI 754132 is given to humans for the first time. The doctors compare how well participants tolerate the different doses of BI 754132. The doctors also regularly check the general health of the participants.

Timeline

Start
2019-07-26
Primary completion
2022-08-09
Completion
2022-08-09

Outcome

Outcome not reported

Stopped: “The trial was discontinued in the interests of patients considering benefit/risk balance.”

Drugs

EvaluationDrugModalityDoseRoute
Subject BI 754132 Unknown 0.3 mg Intravitreal
Subject BI 754132 Unknown 1 mg Intravitreal
Subject BI 754132 Unknown 3 mg Intravitreal
Subject BI 754132 Unknown 6 mg Intravitreal