drugset / Trial / NCT04018274
Effect of PF-06651600 on the Pharmacokinetics of Oral Contraceptive Steroids
RandomizedCrossoverOpen-labelBasic science
Summary
This is a Phase 1, randomized, 2 way crossover, open-label study of the effect of multiple-dose PF 06651600 on single-dose oral contraceptive (OC) pharmacokinetics (PK) in healthy female subjects. Subjects will be randomized to 1 of 2 treatment sequences. A total of 28 healthy female subjects (14 in each treatment sequence) will be enrolled in the study. Each treatment sequence will consist of 2 periods.
Timeline
- Start
- 2019-08-09
- Primary completion
- 2019-10-16
- Completion
- 2019-10-16
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Levonorgestrel | Small molecule | 150 ug | Oral |
| Subject | Ritlecitinib | Small molecule | 50 mg | Oral |
| Subject | ethinyl estradiol | Small molecule | 30 ug | Oral |
Indications
No indication recorded.