Anakinra as a Rescue Treatment for Allergic Inflammation

Summary

Participants with mild asthma who are sensitized to either house dust mite or cat hair allergen will undergo nasal instillation of the allergen to elicit nasal allergy symptoms. The participants will be treated in a cross-over fashion with either placebo (saline) or anakinra to determine if anakinra will reduce nasal airway eosinophil recruitment, eosinophil activation, release of inflammatory mediators, mucins, and gene expression changes in epithelial cells.

Timeline

Start

2019-12-16

Primary completion

2022-10

Completion

2023-10

Drugs

Indications