drugset / Trial / NCT04036409
Optimal Blood Pressure for the prevenTIon of Major vAscuLar Events in Stroke Patients
Active not recruiting
4368 enrolled
Hospital Israelita Albert Einstein
Ministry of Health, Brazil · collab
RandomizedParallel-groupSingle-blindTreatment
Summary
Elevated blood pressure (BP) consists of a major public health concern especially in low and middle income countries. Besides being a highly prevalent condition, it is also a risk factor for several major cardiovascular events including stroke (which consists of the second leading cause of death in developing countries) and coronary artery disease, and is also related to cognitive decline. The OPTIMAL Stroke trial consists of a two-arm, multicenter, randomized clinical trial designed to test whether a lower target systolic blood pressure (SBP) as compared to the currently recommended target for stroke patients will reduce the occurrence of major cardiovascular events.
Timeline
- Start
- 2019-08-05
- Primary completion
- 2026-05-28
- Completion
- 2026-05-28
Publications
- Saiz LC, Gorricho J, Garjon J, Celaya MC, Erviti J, Leache L. Blood pressure targets for the treatment of people with hypertension and cardiovascular disease. Cochrane Database Syst Rev. 2022 Nov 18;11(11):CD010315. doi: 10.1002/14651858.CD010315.pub5.
- Saiz LC, Gorricho J, Garjon J, Celaya MC, Erviti J, Leache L. Blood pressure targets for the treatment of people with hypertension and cardiovascular disease. Cochrane Database Syst Rev. 2020 Sep 9;9(9):CD010315. doi: 10.1002/14651858.CD010315.pub4.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Background | Amlodipine | Other / unclassified | — | — |
| Background | Indapamide | Small molecule | — | — |
| Background | Perindopril | Small molecule | — | — |