Crystalloid Fluid Choice and Neurological Outcome in Patients After Subarachnoid Haemorrhage

Summary

Patients with subarachnoid hemorrhage are prone to suffer from dysnatriemia. Evidence shows that hyponatriemia is associated with increased incidence of vasospasm, brain swelling and mortality in these patients. Patients with subarachnoid hemorrhage often require large amounts of iv fluids in order to maintain euvolemia and support cardiocirculatory function. Prior evidence shows that the type of infusion fluid significantly influences blood sodium content. Hence, this study evaluated whether the sodium content of the infusion solution impacts mortality and morbidity in patients with subarachnoid hemorrhage.

Timeline

Start

2022-05-24

Primary completion

2027-07

Completion

2027-12

Publications

• Background Messmer AS, Pitteloud M, Quintard H, Pietsch U, Muller M, Filipovic M, Jakob SM, Z'Graggen WJ, Schefold JC, Pfortmueller CA. CRYSTALLBrain: crystalloid fluid choice and neurological outcome in patients with non-traumatic subarachnoid haemorrhage-a study protocol for a multi-centre randomised double-blind clinical trial. Trials. 2025 Oct 17;26(1):422. doi: 10.1186/s13063-025-09099-9.
• Mistry AM. Which Intravenous Isotonic Fluid Offers Better Outcomes for Patients with a Brain Injury? Neurocrit Care. 2025 Apr;42(2):715-721. doi: 10.1007/s12028-024-02139-3. Epub 2024 Oct 8.

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