Higher vs. Lower Dose Heparin for PCI

Summary

HD PCI is a multicenter, randomized, registry-based, cluster crossover design trial of higher dose versus lower dose heparin in patients undergoing elective percutaneous coronary intervention (PCI).

Timeline

Start

2022-03-02

Primary completion

2024-10-08

Completion

2025-12

Publications

• d'Entremont MA, Lee SF, Wijeysundera HC, Tsang MB, Amlani S, Wassef A, Lavi S, So DYF, Betz J, Tyrwhitt J, Graham J, Cantor WJ, Bagherli A, Vijayaraghavan R, Jolly SS. Design and rationale of the HD PCI trial: A cluster randomized crossover trial of higher vs. lower dose heparin for elective percutaneous coronary intervention. Am Heart J. 2026 Apr;294:107330. doi: 10.1016/j.ahj.2025.107330. Epub 2025 Dec 22.

Drugs

Indications