Closed-loop Control of Penicillin Delivery

Phase 1 Completed 6 enrolled Imperial College London

Non-randomizedSingle-groupOpen-labelDevice feasibility

Summary

This study is an in-house feasibility study of penicillin biosensor technology linked with closed-loop control for the automated delivery of penicillin antibiotics.

Timeline

Start: 2019-11-05
Primary completion: 2024-05-31
Completion: 2024-05-31

Publications

Background Gowers SAN, Freeman DME, Rawson TM, Rogers ML, Wilson RC, Holmes AH, Cass AE, O'Hare D. Development of a Minimally Invasive Microneedle-Based Sensor for Continuous Monitoring of beta-Lactam Antibiotic Concentrations in Vivo. ACS Sens. 2019 Apr 26;4(4):1072-1080. doi: 10.1021/acssensors.9b00288. Epub 2019 Apr 17.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Benzylpenicillin	Unknown	600 mg	Intravenous
Subject	Benzylpenicillin	Unknown	1200 mg	Intravenous
Subject	Benzylpenicillin	Unknown	2400 mg	Intravenous

Indications

No indication recorded.