Tulobuterol Patch in Pediatric Patients Undergoing Tonsillectomy

Summary

* Tonsillectomy is a common pediatric procedure for the treatment of sleep-disordered breathing and chronic tonsillitis. Up to half of children having this procedure experience a perioperative respiratory adverse event. * We tried to determine whether tulobuterol patch (transdermal bronchodilator) premedication decreases the risk of perioperative respiratory adverse events in children undergoing anesthesia for tonsillectomy.

Timeline

Start

2019-12-20

Primary completion

2021-09-30

Completion

2021-09-30

Outcome

Met primary endpoint

paper The incidence of any perioperative respiratory adverse event was lower with tulobuterol (n = 13/88; 14.7%) than that with the placebo (n = 40/94; 42.5%), PMID 36727868 ↗

paper with an estimated average relative risk (95% confidence interval) across components of 0.35 (0.20-0.60; P < .001). PMID 36727868 ↗

Publications

• Kim EH, Lee SH, Kim JK, Park YH, Kang P, Park JB, Ji SH, Jang YE, Lee JH, Kim JT, Kim HS. Effect of Tulobuterol Patch Versus Placebo on the Occurrence of Respiratory Adverse Events in Children Undergoing Tonsillectomies: A Randomized Controlled Trial. Anesth Analg. 2023 Jun 1;136(6):1067-1074. doi: 10.1213/ANE.0000000000006355. Epub 2023 May 19.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Tulobuterol	Small molecule	1 mg	Other

Indications

No indication recorded.