drugset / Trial / NCT04064190
Vactosertib with Durvalumab in Urothelial Carcinoma Failing Checkpoint Inhibition
NaSingle-groupOpen-labelTreatment
Summary
This is Phase 2, open label, non randomized single arm study to determine whether the administration of vactosertib with durvalumab will provide meaningful increases in the Overall Response Rate (ORR) in patients with urothelial cancers that fail to achieve a response with anti-PD-1/PD-L1 based regimens
Timeline
- Start
- 2019-12-13
- Primary completion
- 2023-12-30
- Completion
- 2024-12-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Durvalumab | Monoclonal antibody | 1500 mg | Intravenous |
| Subject | Vactosertib | Small molecule | 300 mg | Oral |