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drugset / Trial / NCT04068532

A Study to Explore Pharmacodynamic Effects of BIIB104 on Brain Circuitry in Healthy Participants

NCT04068532 ↗

Phase 1 Completed 30 enrolled Biogen
RandomizedCrossoverTriple-blindTreatment

Summary

The primary objective of the study is to explore the pharmacodynamic (PD) effects of BIIB104 on brain circuitry associated with emotional processing in healthy participants. The secondary objectives of the study are to evaluate the safety and tolerability of BIIB104 in healthy participants; To further explore the PD effects of BIIB104 on brain circuitry associated with emotional processing in healthy participants; To explore the PD effects of BIIB104 on brain circuitry associated with working memory in healthy participants using the N-Back; To explore the PD effects of BIIB104 on regional cerebral blood flow (CBF) in healthy participants; To explore the PD effects of BIIB104 on brain circuitry during resting state in healthy participants.

Timeline

Start
2019-11-15
Primary completion
2020-11-11
Completion
2020-11-11

Drugs

EvaluationDrugModalityDoseRoute
Subject PESAMPATOR Small molecule — —

Indications

No indication recorded.