Effects of PDT and Bioceramic Filling on Periapical Healing and Postoperative Pain After Endodontic Retreatment

Phase 0 Completed 70 enrolled Medical Innovation Center Wroclaw University of Zagreb · collab

RandomizedParallel-groupSingle-blindTreatment

Summary

The purpose is to investigate influence of bioceramic filling of the root canal and photodynamic therapy on periapical healing and development of postoperative pain after endodontic retreatment. Patients are divided into two main groups and each of the group is divided into two subgroups. Main groups are patients receiving photodynamic therapy and patients receiving passive ultrasonic irrigation. Each of the main group is divided by the root canal filling material on the AH+ group and BioRoot group.

Timeline

Start: 2019-10-16
Primary completion: 2021-12-31
Completion: 2022-12-31

Outcome

Missed primary endpoint

paper Pre- and postoperative PL volumes (p > 0.05) were not significantly different between the CSBS and ERBS groups. PMID 41375569 ↗

Publications

Pazin B, Lauc T, Petricevic GK, Gabric D, Bago I. Periapical Lesion Healing After Retreatment and Root Canal Filling with a Bioceramic-Based Sealer: A Randomized Clinical Study with 1-Year Follow-Up. J Clin Med. 2025 Nov 21;14(23):8267. doi: 10.3390/jcm14238267.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	BioRoot	Unknown	—	—