A Study to Assess the Safety, Tolerability and Efficacy of IONIS-AGT-LRx

Summary

This study evaluated the effect of ISIS 757456 (IONIS-AGT-LRx) on plasma angiotensinogen (AGT) and systolic blood pressure (SBP) in uncontrolled hypertensive participants who were on two to three antihypertensive medications.

Timeline

Start

2019-11-13

Primary completion

2020-07-20

Completion

2020-07-20

Outcome

Met primary endpoint

registry analysis (superiority test); Placebo vs ISIS 757456; p < 0.001; ANOVA; NCT04083222 ↗

Publications

• Lidani KCF, Trainor PJ, Buscaglia R, Foster K, Jaramillo S, Michael K, Landry AP, Michos ED, Ouyang P, Morgan ES, Tsimikas S, DeFilippis AP. Circulating Levels of Angiotensinogen, Sex Hormones, and Hormone Therapy-The Multi-Ethnic Study of Atherosclerosis (MESA). J Clin Hypertens (Greenwich). 2025 Jun;27(6):e70083. doi: 10.1111/jch.70083.

Drugs

Indications