drugset / Trial / NCT04084860
The Role of Brief Potent Glutamatergic Modulation in Addressing Problem Drinking
Phase 2
Recruiting
120 enrolled
New York State Psychiatric Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA) · collab
RandomizedFactorialQuadruple-blindTreatment
Summary
The proposed project tests the efficacy of glutamate modulators in non-depressed individuals with alcohol use disorder (AUD); the primary hypothesis is that the glutamate modulator being tested reduces heavy drinking days compared to the active control. It also aims to investigate, using a 2 by 2 factorial (2x2) design, the hypothesis that the effects of the glutamate modulator are enhanced when combined with behavioral treatment.
Timeline
- Start
- 2019-11-08
- Primary completion
- 2024-08-31
- Completion
- 2024-08-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | CI-581a | Unknown | 0.71 mg/kg | — |
| Comparator | CI-581b | Unknown | 0.0125 mg/kg | — |