Short Term Effect of Vitamin D Supplementation on the Clinical Outcomes in Patients Undergoing Valve Replacement Surgery

Summary

This study evaluates the effect of Vitamin D supplementation on ICU and hospital LOS in patients undergoing valve replacement surgery. Half of the patients will receive Alfacalcidol, while the other half-the control group- will be exposed to the same environment without receiving alfacalcidol.

Timeline

Start

2017-04-01

Primary completion

2018-02-26

Completion

2019-09-03

Outcome

Met primary endpoint

paper Treatment with alfacalcidol was associated with a statistically significant decrease in ICU LOS (hazard ratio = 1.61; 95% CI, 1.77-2.81; P = 0.041) PMID 33339609 ↗

paper and hospital LOS (hazard ratio = 1.63; 95% CI, 1.04-2.55; P = 0.034). PMID 33339609 ↗

Publications

• Naguib SN, Sabry NA, Farid SF, Alansary AM. Short-term Effects of Alfacalcidol on Hospital Length of Stay in Patients Undergoing Valve Replacement Surgery: A Randomized Clinical Trial. Clin Ther. 2021 Jan;43(1):e1-e18. doi: 10.1016/j.clinthera.2020.11.008. Epub 2020 Dec 16.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Alfacalcidol	Other / unclassified	2 ug	Oral

Indications