Safety, Tolerability and Preliminary Efficacy of Multiple Intra-articular Injections of LRX712 in Patients With Knee OA

Summary

This study explored the preliminary efficacy of multiple intra-articular injections of LRX712 by evaluating the ability of the drug to restore structural integrity of articular cartilage. Efficacy was evaluated in the context of the systemic safety and local tolerability of the investigational drug.

Timeline

Start

2020-07-20

Primary completion

2024-08-08

Completion

2025-01-17

Outcome

Missed primary endpoint

registry analysis (superiority test); LRX712 15 mg vs Placebo; p = 0.2366 NCT04097379 ↗

registry analysis (superiority test); LRX712 25 mg vs Placebo; p = 0.2892 NCT04097379 ↗

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	LRX712	Unknown	15 mg	Other
Subject	LRX712	Unknown	25 mg	Other
Subject	LRX712	Unknown	75 mg	Other

Indications