Fresh Frozen Plasma as a Substitute for Albumin in Patients Receiving a Large Volume Paracentesis

Summary

Large volume paracentesis (LVP) with albumin administration is the standard of care for patients with refractory ascites complicating end-stage liver disease. However, the use of albumin is frequently limited due to expense and occasional short supply. The goal of this study is to determine if the administration of Fresh Frozen Plasma (FFP) during large volume paracentesis is effective in lowering plasma renin activity by 25% compared to baseline.

Timeline

Start

2019-11-11

Primary completion

2023-07

Completion

2023-07

Outcome

Outcome not reported

Stopped (Enrollment): “PI confirmed that while coordination and planning was conducted upon IRB approval, no participants were enrolled into the study”

Drugs

Indications