Exercise Plus Duloxetine for Knee Osteoarthritis

Phase 2 Completed 43 enrolled University of Maryland, Baltimore National Institute on Aging (NIA) · collab

NaSingle-groupOpen-labelTreatment

Summary

This study evaluates the addition of duloxetine to aerobic exercise in the treatment of symptomatic knee osteoarthritis and depressive symptoms in adults. All participants will receive the receive the treatment protocol, which will first be evaluated in terms of feasibility and then pilot tested.

Timeline

Start: 2021-10-07
Primary completion: 2025-08-11
Completion: 2025-08-11

Publications

Rathbun AM, Mehta R, Ryan AS, Dong Y, Beamer B, Golden J, Gallo JJ, Luborsky M, Shardell MD, Peer JE, Hochberg MC. Duloxetine plus exercise for knee osteoarthritis and depression: A feasibility study. Osteoarthr Cartil Open. 2023 Dec 8;6(1):100426. doi: 10.1016/j.ocarto.2023.100426. eCollection 2024 Mar.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Duloxetine	Small molecule	60 mg	—
Subject	Duloxetine	Small molecule	90 mg	—

Exercise Plus Duloxetine for Knee Osteoarthritis

Summary

Timeline

Publications

Drugs

Indications