The Effects of Topical Corticosteroid Use on Insulin Sensitivity and Bone Turnover

Summary

The investigators believe that the emerging epidemiological evidence connecting topical use of corticosteroids to the development of type 2 diabetes and osteoporosis point to potentially massive, yet clinically unacknowledged problems associated with topical corticosteroid treatment. Using state-of-the-art methodology, the present study will delineate the impact of topical corticosteroid use on insulin sensitivity and bone turnover markers in patients with atopic dermatitis and, thus, provide important data that may have implications for millions of people using topical corticosteroids.

Timeline

Start

2019-08-22

Primary completion

2021-03-15

Completion

2021-03-15

Publications

• Amiri D, Hellmann PH, Thyssen JP, Skov L, Kolko M, Gether L. Intraocular Pressure During Short-Term Topical or Systemic Corticosteroid Treatment: Analysis of 3 Randomized Clinical Trials. JAMA Dermatol. 2026 May 13:e261183. doi: 10.1001/jamadermatol.2026.1183. Online ahead of print.
• Gether L, Storgaard H, Kezic S, Jakasa I, Hartmann B, Skov-Jeppesen K, Holst JJ, Pedersen AJ, Forman J, van Hall G, Sorensen OE, Skov L, Ropke MA, Knop FK, Thyssen JP. Effects of topical corticosteroid versus tacrolimus on insulin sensitivity and bone homeostasis in adults with atopic dermatitis-A randomized controlled study. Allergy. 2023 Jul;78(7):1964-1979. doi: 10.1111/all.15690. Epub 2023 Mar 21.

Drugs

Indications