drugset / Trial / NCT04120363
Trial of Testosterone Undecanoate for Optimizing Performance During Military Operations
Phase 4
Completed
34 enrolled
Pennington Biomedical Research Center
United States Army Research Institute of Environmental Medicine · collabUnited States Department of Defense · collabUniversity of Arkansas · collab
RandomizedParallel-groupQuadruple-blindPrevention
Summary
The objective of this study is to determine the effects of a single dose of testosterone undecanoate during and in recovery from simulated operational stress.
Timeline
- Start
- 2019-09-23
- Primary completion
- 2021-07-08
- Completion
- 2021-07-08
Publications
- Lowe AC, Niclou A, Varanoske AN, Harris MN, Hebert C, Johannsen NM, Heymsfield SB, Greenway FL, Margolis LM, Lieberman HR, Beyl RA, Ferrando AA, Pasiakos SM, Rood JC. Exercise Heart Rate Variability Suggests Parasympathetic Hyperactivity during Simulated Military Operations Irrespective of Testosterone Administration. Med Sci Sports Exerc. 2025 Sep 1;57(9):1979-1987. doi: 10.1249/MSS.0000000000003743. Epub 2025 Apr 25.
- Varanoske AN, Harris MN, Hebert C, Johannsen NM, Heymsfield SB, Greenway FL, Ferrando AA, Rood JC, Pasiakos SM. Bioelectrical impedance phase angle is associated with physical performance before but not after simulated multi-stressor military operations. Physiol Rep. 2023 Mar;11(6):e15649. doi: 10.14814/phy2.15649.
- Wong MC, Bennett JP, Leong LT, Tian IY, Liu YE, Kelly NN, McCarthy C, Wong JMW, Ebbeling CB, Ludwig DS, Irving BA, Scott MC, Stampley J, Davis B, Johannsen N, Matthews R, Vincellette C, Garber AK, Maskarinec G, Weiss E, Rood J, Varanoske AN, Pasiakos SM, Heymsfield SB, Shepherd JA. Monitoring body composition change for intervention studies with advancing 3D optical imaging technology in comparison to dual-energy X-ray absorptiometry. Am J Clin Nutr. 2023 Apr;117(4):802-813. doi: 10.1016/j.ajcnut.2023.02.006. Epub 2023 Feb 14.
- Varanoske AN, Harris MN, Hebert C, Howard EE, Johannsen NM, Heymsfield SB, Greenway FL, Margolis LM, Lieberman HR, Church DD, Ferrando AA, Rood JC, Pasiakos SM. Effects of testosterone undecanoate on performance during multi-stressor military operations: A trial protocol for the Optimizing Performance for Soldiers II study. Contemp Clin Trials Commun. 2021 Jul 3;23:100819. doi: 10.1016/j.conctc.2021.100819. eCollection 2021 Sep.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Testosterone Undecanoate | Small molecule | 750 mg | Intramuscular |
Indications
No indication recorded.