drugset / Trial / NCT04121299

Mechanism of Masked Hypertension - Intervention

NCT04121299

RandomizedCrossoverQuadruple-blindTreatment

Summary

To test the hypothesis that sympatholytic antihypertensive antihypertensive therapy (αβ-blocker - carvedilol) will reduce out-of-clinic ambulatory BP to a greater extent by blocking sympathetic activity than non-sympatholytic antihypertensive medication (dihydropyridine calcium channel blocker - amlodipine) in individuals with masked hypertension.

Timeline

Start
2021-07
Primary completion
2026-06
Completion
2026-06

Drugs

EvaluationDrugModalityDoseRoute
Comparator Amlodipine Other / unclassified 10 mg
Subject Carvedilol Other / unclassified 40 mg

Indications