drugset / Trial / NCT04121299
Mechanism of Masked Hypertension - Intervention
RandomizedCrossoverQuadruple-blindTreatment
Summary
To test the hypothesis that sympatholytic antihypertensive antihypertensive therapy (αβ-blocker - carvedilol) will reduce out-of-clinic ambulatory BP to a greater extent by blocking sympathetic activity than non-sympatholytic antihypertensive medication (dihydropyridine calcium channel blocker - amlodipine) in individuals with masked hypertension.
Timeline
- Start
- 2021-07
- Primary completion
- 2026-06
- Completion
- 2026-06
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Amlodipine | Other / unclassified | 10 mg | — |
| Subject | Carvedilol | Other / unclassified | 40 mg | — |