MNK-6105 for Patients With Cirrhosis and High Ammonia Levels Affecting Brain Function

Summary

This study is for patients with cirrhosis and hepatic encephalopathy who are in the hospital. This means they have a high ammonia level which is affecting their brain function. All patients will receive the standard of (regular) care. Each will have an equal chance (like flipping a coin) of receiving the experimental drug or placebo along with the standard care. Each patient will have tests during the first 24 hours, receive treatment for up to 5 days, and have 30 days of follow-up.

Timeline

Start

2021-11

Primary completion

2025-04

Completion

2025-07

Drugs

Indications