The Effects of Short-term Preoperative Treatment With Hormonal Therapy on Gene Profiles in Breast Cancer

Phase 2 Completed 30 enrolled Johns Hopkins University Agendia · collab

Non-randomizedParallel-groupOpen-labelBasic science

Summary

The investigators would like to study the genetic and molecular outcomes that results after a short term neoadjuvant hormonal therapy on patients with breast cancer.

Timeline

Start: 2019-02-20
Primary completion: 2022-11-10
Completion: 2022-11-10

Publications

Background Suman VJ, Ellis MJ, Ma CX. The ALTERNATE trial: assessing a biomarker driven strategy for the treatment of post-menopausal women with ER+/Her2- invasive breast cancer. Chin Clin Oncol. 2015 Sep;4(3):34. doi: 10.3978/j.issn.2304-3865.2015.09.01.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Exemestane	Small molecule	25 mg	—
Subject	Letrozole	Other / unclassified	2.5 mg	—
Subject	Tamoxifen	Small molecule	10 mg	—

The Effects of Short-term Preoperative Treatment With Hormonal Therapy on Gene Profiles in Breast Cancer

Summary

Timeline

Publications

Drugs

Indications