Fecal Microbiota Transplant (FMT) Capsule for Improving the Efficacy of Anti- PD-1

Summary

To determine whether the fecal microbiota transplant (FMT) capsule can help reverse the resistance of anti-PD-(L)1 treatment in Gastrointestinal (GI) cancer patients.

Timeline

Start

2019-12-05

Primary completion

2023-02-01

Completion

2024-01-29

Publications

• Zhang Y, Xu X, Wang S, Yin X, Zhang B, Zhu Z, Ji R, Zhu J, He H, Cheng S, Han Z, Xie T, Zhang X, Wang Y, Shen S, Kou Y, Bao S, Liu Y, Cao B, Bonny C, Guo X, Segal E, Tan Y, Shen L, Peng Z. Fecal microbiota transplantation combined with anti-PD-1 therapy in refractory microsatellite-stable gastric cancer: a phase I feasibility and safety study. J Immunother Cancer. 2026 Mar 23;14(3):e013823. doi: 10.1136/jitc-2025-013823.

Drugs

Indications