Aerosol Particle Size and Breathing Pattern During Inhaled Furosemide

Phase 1 Unknown 20 enrolled Oxford Brookes University

RandomizedFactorialSingle-blindBasic science

Summary

The study hypothesises that the variability in relief of air hunger with inhaled furosemide that is reported in previous studies can be explained by the breathing pattern adopted during the inhalation and the droplet size in the aerosol, both of which would influence the site of deposition of the aerosol in the lungs

Timeline

Start: 2019-10-14
Primary completion: 2020-09
Completion: 2020-09

Publications

Background Grogono JC, Butler C, Izadi H, Moosavi SH. Inhaled furosemide for relief of air hunger versus sense of breathing effort: a randomized controlled trial. Respir Res. 2018 Sep 20;19(1):181. doi: 10.1186/s12931-018-0886-9.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Furosemide	Other / unclassified	40 mg	Inhaled

Indications

No indication recorded.