VItamin C in Thermal injuRY: The VICToRY Trial

Phase 3 Suspended 666 enrolled Clinical Evaluation Research Unit at Kingston General Hospital University of Wuerzburg · collab

RandomizedSingle-groupQuadruple-blindTreatment

Summary

This study aims to show that giving high dose, intravenous vitamin C in addition to standard care to burned critically ill patients will be associated with less organ dysfunction, improved survival and a quicker rate of recovery. In this study, all patients will receive standard care and of the patients will also receive high dose intravenous vitamin C, while the other half of patients will receive placebo.

Timeline

Start: 2020-07-24
Primary completion: 2025-12-18
Completion: 2026-03-31

Publications

Stoppe C, Hill A, Cancio LC, Day AG, Pruskowski KA, Turgeon AF, Pham T, Belisle S, Martinez-Jimenez MA, Limper U, Gille J, Wisler J, Savetamal A, Pollack J, Grau Dominguez D, Jennes S, Shupp JW, Jeschke MG, Colpaert K, Hundeshagen G, Beier JP, Muangman P, Echeverri McCandless A, Meybohm P, Grune T, Dresen E, Weber D, Guttler C, Lew CCH, Jiang X, Froese S, Dansereau M, Lee ZY, Heyland DK; VICTORY Study Team. High-Dose Intravenous Vitamin C and Mortality and Organ Dysfunction in Severe Burn Injury: The VICTORY Randomized Clinical Trial. JAMA. 2026 Jun 10:e2610616. doi: 10.1001/jama.2026.10616. Online ahead of print.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Vitamin C	Other / unclassified	50 mg/kg	Intravenous

Indications

No indication recorded.