drugset / Trial / NCT04142788

RELieving Increasing oEdema Due to Heart Failure

NCT04142788 ↗

RandomizedParallel-groupSingle-blindTreatment

Summary

This trial will investigate the potential for patiromer-facilitated use of higher doses of mineralocorticoid antagonists in addition to standard care (compared to standard care alone) to improve congestion, well-being and mortality in people who have worsening congestion due to heart failure and hyperkalaemia.

Timeline

Start
2020-08-26
Primary completion
2022-12-20
Completion
2022-12-20

Outcome

Outcome not reported

Stopped (Enrollment): “The study was stopped due to low recruitment, which the Steering Committee and funder agreed could not be rectified.”

Drugs

EvaluationDrugModalityDoseRoute
Subject Eplerenone Unknown 50 mg —
Subject Patiromer Other / unclassified 8.4 g —
Subject Patiromer Other / unclassified 25.2 g —
Subject Spironolactone Small molecule 200 mg —